Doctoral Researcher


Name Thornton Fokkens
Affiliation
Rudolf Virchow Center for Integrative and Translational Bioimaging
Street Josef-Schneider-Str. 2 D15
Zip Code 97080
City Würzburg
Email
Telephone
Homepage Homepage
Section Biomedicine
Title of Thesis Project Investigation of the novel Leishmania protein PKH
Primary Supervisor Dr. Sonja Lorenz now Max Planck Institute for Biophysical Chemistry Göttingen
Member of Thesis Committee Prof. Dr. Christian Janzen
Prof. Dr. Thomas Rudel
Dr. Katrin Rittinger, The Francis Crick Institute, London UK
Conference Contribution
Publication

Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1. Düring J, Wolter M, Toplak JJ, Torres C, Dybkov O, Fokkens TJ, Bohnsack KE, Urlaub H, Steinchen W, Dienemann C, Lorenz S. Nat Struct Mol Biol. 2024 Feb;31(2):364-377. doi: 10.1038/s41594-023-01203-4. Epub 2024 Feb 8.

Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Kokic G, Yakoub G, van den Heuvel D, Wondergem AP, van der Meer PJ, van der Weegen Y, Chernev A, Fianu I, Fokkens TJ, Lorenz S, Urlaub H, Cramer P, Luijsterburg MS. Nat Struct Mol Biol. 2024 Mar;31(3):536-547. doi: 10.1038/s41594-023-01207-0. Epub 2024 Feb 5.

Zinc finger 1 of the RING E3 ligase, RNF125, interacts with the E2 to enhance ubiquitylation. Middleton AJ, Barzak FM, Fokkens TJ, Nguyen K, Day CL. Structure. 2023 Oct 5;31(10):1208-1219.e5. doi: 10.1016/j.str.2023.07.007. Epub 2023 Aug 3.
Last update Publications 05.08.2023