Doctoral Researcher


Name Leonie Uhl
Affiliation Theodor-Boveri-Institute (Biocenter)
Chair of Biochemistry and Molecular Biology
Street Am Hubland
Zip Code 97074
City Würzburg
Email E-mail
Telephone +49 931 31- 87202
Homepage Homepage
Section Biomedicine
Title of Thesis Project UBR5-mediated control of MYC-dependent transcription regulation and DNA damage signaling in response to promotor-proximal R-loop formation
Primary Supervisor Prof. Dr. Martin Eilers
Member of Thesis Committee Prof. Dr. Alexander Buchberger
Prof. Dr. Matthias Altmeyer, University of Zurich, Switzerland
Conference Contribution
Publication Personal Formatting

The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex. Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. 

Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia. Taylor J, Uhl L, Moll I, Hasan SS, Wiedmann L, Morgenstern J, Giaimo BD, Friedrich T, Alsina-Sanchis E, De Angelis Rigotti F, Mülfarth R, Kaltenbach S, Schenk D, Nickel F, Fleming T, Sprinzak D, Mogler C, Korff T, Billeter AT, Müller-Stich BP, Berriel Diaz M, Borggrefe T, Herzig S, Rohm M, Rodriguez-Vita J, Fischer A. Nat Cancer. 2023 Nov;4(11):1544-1560. doi: 10.1038/s43018-023-00622-y. Epub 2023 Sep 25.

Beyond gene expression: how MYC relieves transcription stress. Papadopoulos D, Uhl L, Ha SA, Eilers M. Trends Cancer. 2023 Oct;9(10):805-816. doi: 10.1016/j.trecan.2023.06.008. Epub 2023 Jul 7.

MYC multimers shield stalled replication forks from RNA polymerase. Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. 
Last update Publications 11.05.2024