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Doctoral Researcher


Name Patrick Bohn
Affiliation
Helmholtz Institute for RNA-based Infection Research HIRI
Street Josef-Schneider-Str. 2 D15
Zip Code 97080
City Würzburg
Email E-mail
Telephone
Homepage Homepage
Section Infection & Immunity
Title of Thesis Project Single molecule RNA structural probing for the study of viral RNA structures
Primary Supervisor Jun.-Prof. Dr. Redmond Smyth
Member of Thesis Committee Prof. Dr. Lars Dölken now Hannover Medical School
Prof. Dr. Claudia Höbartner
Prof. Lars Barquist now University Toronto Canada
Conference Contribution
Publication

Sequencing accuracy and systematic errors of nanopore direct RNA sequencing. Liu-Wei W, van der Toorn W, Bohn P, Hölzer M, Smyth RP, von Kleist M. BMC Genomics. 2024 May 28;25(1):528. doi: 10.1186/s12864-024-10440-w. 

Recruitment of multi-segment genomic RNAs by Bluetongue virus requires a preformed RNA network. Sung PY, Phelan JE, Luo D, Kulasegaran-Shylini R, Bohn P, Smyth RP, Roy P. Nucleic Acids Res. 2024 Aug 12;52(14):8500-8514. doi: 10.1093/nar/gkae404. 

Isoform-specific RNA structure determination using Nano-DMS-MaP. Gribling-Burrer AS, Bohn P, Smyth RP. Nat Protoc. 2024 Jun;19(6):1835-1865. doi: 10.1038/s41596-024-00959-3. Epub 2024 Feb 12.

Alternative translation contributes to the generation of a cytoplasmic subpopulation of the Junín virus nucleoprotein that inhibits caspase activation and innate immunity. Bostedt L, Fénéant L, Leske A, Holzerland J, Günther K, Waßmann I, Bohn P, Groseth A. J Virol. 2024 Feb 20;98(2):e0197523. doi: 10.1128/jvi.01975-23. Epub 2024 Jan 31.

Nano-DMS-MaP allows isoform-specific RNA structure determination. Bohn P, Gribling-Burrer AS, Ambi UB, Smyth RP. Nat Methods. 2023 Jun;20(6):849-859. doi: 10.1038/s41592-023-01862-7. Epub 2023 Apr 27.

Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging. Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP. Nat Struct Mol Biol. 2022 Apr;29(4):306-319. doi: 10.1038/s41594-022-00746-2. Epub 2022 Mar 28.

A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein. Bohn P, Waßmann I, Wendt L, Leske A, Hoenen T, Tews BA, Groseth A. PLoS Pathog. 2023 Jan 5;19(1):e1011049. doi: 10.1371/journal.ppat.1011049. eCollection 2023 Jan. 

RNA Structures and Their Role in Selective Genome Packaging. Ye L, Ambi UB, Olguin-Nava M, Gribling-Burrer AS, Ahmad S, Bohn P, Weber MM, Smyth RP. Viruses. 2021 Sep 8;13(9):1788. doi: 10.3390/v13091788.

 

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. Lang J, Bohn P, Bhat H, Jastrow H, Walkenfort B, Cansiz F, Fink J, Bauer M, Olszewski D, Ramos-Nascimento A, Duhan V, Friedrich SK, Becker KA, Krawczyk A, Edwards MJ, Burchert A, Huber M, Friebus-Kardash J, Göthert JR, Hardt C, Probst HC, Schumacher F, Köhrer K, Kleuser B, Babiychuk EB, Sodeik B, Seibel J, Greber UF, Lang PA, Gulbins E, Lang KS. Nat Commun. 2020 Mar 12;11(1):1338. doi: 10.1038/s41467-020-15072-8.

 

Assessing cross-reactivity of Junín virus-directed neutralizing antibodies. Leske A, Waßmann I, Schnepel K, Shifflett K, Holzerland J, Bostedt L, Bohn P, Mettenleiter TC, Briggiler AM, Brignone J, Enria D, Cordo SM, Hoenen T, Groseth A. Antiviral Res. 2019 Mar;163:106-116. doi: 10.1016/j.antiviral.2019.01.006. Epub 2019 Jan 19.

 

Last update Publications 01.06.2024

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