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Doctoral Researcher


Name Alexandra Cirnu
Affiliation Comprehensive Heart Failure Center CHFC
Department Kardiovaskuläre Genetik
Street Am Schwarzenberg 15
Zip Code 97078
City Würzburg
Email E-mail
Telephone
Homepage Homepage
Section Biomedicine
Title of Thesis Project Characterization of Titin-related Cardiomyopathies
Primary Supervisor Prof. Dr. Brenda Gerull
Member of Thesis Committee Prof. Dr. Christoph Maack
Prof. Dr. Eva Klopocki
Prof. Dr. Christian Stigloher
Conference Contribution
Publication

Macro-based collagen quantification and segmentation in picrosirius red-stained heart sections using light microscopy. Kammerer J, Cirnu A, Williams T, Hasselmeier M, Nörpel M, Chen R, Gerull B. Biol Methods Protoc. 2024 Apr 27;9(1):bpae027. doi: 10.1093/biomethods/bpae027. eCollection 2024. 

Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes. Janz A, Walz K, Cirnu A, Surjanto J, Urlaub D, Leskien M, Kohlhaas M, Nickel A, Brand T, Nose N, Wörsdörfer P, Wagner N, Higuchi T, Maack C, Dudek J, Lorenz K, Klopocki E, Ergün S, Duff HJ, Gerull B. Mol Metab. 2024 Jan;79:101859. doi: 10.1016/j.molmet.2023.101859. Epub 2023 Dec 23.

Mechanistic Insights of the LEMD2 p.L13R Mutation and Its Role in Cardiomyopathy. Chen R, Buchmann S, Kroth A, Arias-Loza AP, Kohlhaas M, Wagner N, Grüner G, Nickel A, Cirnu A, Williams T, Maack C, Ergün S, Frantz S, Gerull B. Circ Res. 2023 Jan 20;132(2):e43-e58. doi: 10.1161/CIRCRESAHA.122.321929. Epub 2023 Jan 4. 

CRISPR/Cas9-edited PKP2 knock-out (JMUi001-A-2) and DSG2 knock-out (JMUi001-A-3) iPSC lines as an isogenic human model system for arrhythmogenic cardiomyopathy (ACM). Janz A, Zink M, Cirnu A, Hartleb A, Albrecht C, Rost S, Klopocki E, Günther K, Edenhofer F, Ergün S, Gerull B. Stem Cell Res. 2021 May;53:102256. doi: 10.1016/j.scr.2021.102256. Epub 2021 Feb 18.

 

Novel Mutation in LOX Associates With a Complex Aneurysmal Vascular and Cardiac Phenotype. Cirnu A, Kolokotronis K, Walz K, Kilinç A, Janz A, Williams T, Busch A, Rost S, Gerull B. Circ Genom Precis Med. 2021 Feb;14(1):e003217. doi: 10.1161/CIRCGEN.120.003217. Epub 2021 Feb 1.

 

Last update Publications 01.06.2024

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