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Doctoral Researcher


Name Kai Ziegler-Martin
Affiliation Department of Internal Medicine II
Lehrstuhl für Zelluläre Immuntherapie
Street Versbacher Str. 5
Zip Code 97078
City Würzburg
Email E-mail
Telephone +49 931 201- 71294
Homepage
Section Infection & Immunity
Title of Thesis Project Modulation of the tumor microenvironment by reprogramming of engineered T cells
Primary Supervisor Junior-Prof. Dr. Maik Luu
Member of Thesis Committee Mercedes Gomez de Agüero, PhD
Prof. Dr. Michael Hudecek
Dr. Emmanuel Donnadieu, Université Paris Cité, France
Conference Contribution
Publication

Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells. Staudt S, Nikolka F, Perl M, Franz J, Leblay N, Yuan XK, Larrayoz M, Lozano T, Warmuth L, Fante MA, Skorpskaite A, Fei T, Bromberg M, San Martin-Uriz P, Rodriguez-Madoz JR, Ziegler-Martin K, Adil-Gholam N, Benz P, Tran Huu P, Stein-Thoeringer C, Schmitt M, Kleigrewe K, Freitag F, Riester Z, Weber J, Mangold K, Ho P, Einsele H, Prosper F, Ellmeier W, Busch D, Visekruna A, Slingerland J, Shouval R, Hiller K, Lasarte JJ, Martinez-Climent JA, Pausch P, Neri P, van den Brink M, Poeck H, Hudecek M, Luu M. bioRxiv [Preprint]. 2025 Feb 4:2024.08.19.608538. doi: 10.1101/2024.08.19.608538. 

Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. Soll D, Chu CF, Sun S, Lutz V, Arunkumar M, Gachechiladze M, Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil MA, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE. Nat Immunol. 2024 Oct;25(10):1830-1844. doi: 10.1038/s41590-024-01918-6. Epub 2024 Aug 28. 

Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells. Luu M, Krause FF, Monning H, Wempe A, Leister H, Mainieri L, Staudt S, Ziegler-Martin K, Mangold K, Kappelhoff N, Shaul YD, Göttig S, Plaza-Sirvent C, Schulte LN, Bekeredjian-Ding I, Schmitz I, Steinhoff U, Visekruna A. Mucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. 

Learning from the microbes: exploiting the microbiome to enforce T cell immunotherapy. Staudt S, Ziegler-Martin K, Visekruna A, Slingerland J, Shouval R, Hudecek M, van den Brink M, Luu M. Front Immunol. 2023 Sep 18;14:1269015. doi: 10.3389/fimmu.2023.1269015. eCollection 2023. 

Last update Publications 20.02.2025

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