Doctoral Researcher Profile


Name Antonios Drakopoulos
Affiliation Institute of Pharmacy and Food Chemistry
Pharmaceutical and Medicinal Chemistry
Street Am Hubland
Zip Code 97074
City Würzburg
Email E-mail
Telephone +49 931 31- 89676
Homepage Homepage
Section Neuroscience
Title of Thesis Project Opioid receptor oligomerization study through fluorescence-based assays
Primary Supervisor Prof. Dr. Michael Decker
Member of Thesis Committee Prof. Dr. Dr. Davide Calebiro now University of Birmingham
Dr. Sebastien Granier, IGF Montpellier
Abstract
Publications

Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes. Drakopoulos A, Koszegi Z, Lanoiselée Y, Hübner H, Gmeiner P, Calebiro D, Decker M. J Med Chem. 2020 Apr 9;63(7):3596-3609. doi: 10.1021/acs.jmedchem.9b02011. Epub 2020 Mar 25.

Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of μ-Opioid Receptor Dimerization. Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M. Angew Chem Int Ed Engl. 2020 Apr 6;59(15):5958-5964. doi: 10.1002/anie.201912683. Epub 2020 Jan 7.

Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants. Drakopoulos A, Tzitzoglaki C, McGuire K, Hoffmann A, Konstantinidi A, Kolokouris D, Ma C, Freudenberger K, Hutterer J, Gauglitz G, Wang J, Schmidtke M, Busath DD, Kolocouris A. ACS Med Chem Lett. 2018 Jan 29;9(3):198-203. doi: 10.1021/acsmedchemlett.7b00458. eCollection 2018 Mar 8.

Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility. Huang G, Drakopoulos A, Saedtler M, Zou H, Meinel L, Heilmann J, Decker M. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4937-4941. doi: 10.1016/j.bmcl.2017.08.045. Epub 2017 Aug 24.

Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited.Drakopoulos A, Tzitzoglaki C, Ma C, Freudenberger K, Hoffmann A, Hu Y, Gauglitz G, Schmidtke M, Wang J, Kolocouris A. ACS Med Chem Lett. 2017 Jan 27;8(2):145-150. doi: 10.1021/acsmedchemlett.6b00311.

Experimental and theoretical investigations into the stability of cyclic aminals. Sawatzky E, Drakopoulos A, Rölz M, Sotriffer C, Engels B, Decker M. Beilstein J Org Chem. 2016 Oct 31;12:2280-2292. doi: 10.3762/bjoc.12.221.

Alchemical Free Energy Calculations and Isothermal Titration Calorimetry Measurements of Aminoadamantanes Bound to the Closed State of Influenza A/M2TM.Ioannidis H, Drakopoulos A, Tzitzoglaki C, Homeyer N, Kolarov F, Gkeka P, Freudenberger K, Liolios C, Gauglitz G, Cournia Z, Gohlke H, Kolocouris A. J Chem Inf Model. 2016 May 23;56(5):862-76. doi: 10.1021/acs.jcim.6b00079. Epub 2016 May 9.

Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders. Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmüller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M. ChemMedChem. 2016 Jun 20;11(12):1270-83. doi: 10.1002/cmdc.201500418. Epub 2015 Nov 9.
Conference Contribution
Last update Publications 14.03.2020