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MYC multimers shield stalled replication forks from RNA polymerase. Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23.
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RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells. Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A. Mol Oncol. 2022 Aug;16(15):2788-2809. doi: 10.1002/1878-0261.13265. Epub 2022 Jul 1.
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PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. Fischer T, Hartmann O, Reissland M, Prieto-Garcia C, Klann K, Pahor N, Schülein-Völk C, Baluapuri A, Polat B, Abazari A, Gerhard-Hartmann E, Kopp HG, Essmann F, Rosenfeldt M, Münch C, Flentje M, Diefenbacher ME. Cell Biosci. 2022 Apr 27;12(1):50. doi: 10.1186/s13578-022-00778-7.
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NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. doi: 10.1073/pnas.2105691119.
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Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U. Nat Commun. 2022 Jan 12;13(1):281. doi: 10.1038/s41467-021-27704-8.
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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts. Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29.
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F, Baluapuri A, Wolf E. Mol Cell. 2021 Aug 5;81(15):3110-3127.e14. doi: 10.1016/j.molcel.2021.06.016. Epub 2021 Jul 6. |
MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma. Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M. Cancer Res. 2021 Aug 15;81(16):4242-4256. doi: 10.1158/0008-5472.CAN-21-1677. Epub 2021 Jun 18. |
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease. Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME. Front Cell Dev Biol. 2021 Mar 2;9:641618. doi: 10.3389/fcell.2021.641618. eCollection 2021.
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Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters. Endres T, Solvie D, Heidelberger JB, Andrioletti V, Baluapuri A, Ade CP, Muhar M, Eilers U, Vos SM, Cramer P, Zuber J, Beli P, Popov N, Wolf E, Gallant P, Eilers M. Mol Cell. 2021 Feb 18;81(4):830-844.e13. doi: 10.1016/j.molcel.2020.12.035. Epub 2021 Jan 15. |
PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Adhikari B, Bozilovic J, Diebold M, Schwarz JD, Hofstetter J, Schröder M, Wanior M, Narain A, Vogt M, Dudvarski Stankovic N, Baluapuri A, Schönemann L, Eing L, Bhandare P, Kuster B, Schlosser A, Heinzlmeir S, Sotriffer C, Knapp S, Wolf E. Nat Chem Biol. 2020 Nov;16(11):1179-1188. doi: 10.1038/s41589-020-00652-y. Epub 2020 Sep 28. |
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S. Oncogene. 2020 Oct;39(44):6841-6855. doi: 10.1038/s41388-020-01477-8. Epub 2020 Sep 25. Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S. Oncogene. 2020 Oct;39(44):6841-6855. doi: 10.1038/s41388-020-01477-8. Epub 2020 Sep 25.
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Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T. Nat Microbiol. 2021 Apr;6(4):533. doi: 10.1038/s41564-021-00874-3. Author Correction: Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T. Nat Microbiol. 2021 Apr;6(4):533. doi: 10.1038/s41564-021-00874-3.
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Target gene-independent functions of MYC oncoproteins. Baluapuri A, Wolf E, Eilers M. Nat Rev Mol Cell Biol. 2020 May;21(5):255-267. doi: 10.1038/s41580-020-0215-2. Epub 2020 Feb 18.
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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Cossa G, Roeschert I, Prinz F, Baluapuri A, Silveira Vidal R, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Mol Cell. 2020 Mar 19;77(6):1322-1339.e11. doi: 10.1016/j.molcel.2020.01.008. Epub 2020 Jan 31. Localized inhibition of protein phosphatase 1 by NUAK1 promotes spliceosome activity and reveals a MYC-sensitive feedback control of transcription. Cossa G, Roeschert I, Prinz F, Baluapuri A, Vidal RS, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Kumar A, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Mol Cell. 2021 Jun 3;81(11):2495. doi: 10.1016/j.molcel.2021.05.013.
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A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A. Nat Cell Biol. 2019 Nov;21(11):1413-1424. doi: 10.1038/s41556-019-0408-0. Epub 2019 Nov 4.
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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes. Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S. Cell Rep. 2019 Jun 18;27(12):3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.
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MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation. Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E. Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031. Epub 2019 Mar 27.
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Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase. Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M. Nature. 2019 Mar;567(7749):545-549. doi: 10.1038/s41586-019-1030-9. Epub 2019 Mar 20.
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Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle. Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M. Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090.
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Whole transcriptome profiling reveals the RNA content of motor axons. Briese M, Saal L, Appenzeller S, Moradi M, Baluapuri A, Sendtner M. Nucleic Acids Res. 2016 Feb 29;44(4):e33. doi: 10.1093/nar/gkv1027. Epub 2015 Oct 12.
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