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Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Groh J, Knöpper K, Arampatzi P, Yuan X, Lößlein L, Saliba AE, Kastenmüller W, Martini R. Nat Aging. 2021 Apr;1(4):357-367. doi: 10.1038/s43587-021-00049-z. Epub 2021 Apr 15.
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Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot-Marie-Tooth 1A. Klein D, Groh J, Yuan X, Berve K, Stassart R, Fledrich R, Martini R. Glia. 2022 Jun;70(6):1100-1116. doi: 10.1002/glia.24158. Epub 2022 Feb 21.
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Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, Yuan X, Genova M, Gadadhar S, Leboucher S, Birling MC, Klein D, Martini R, Janke C, Magiera MM. EMBO J. 2022 Jun 1;41(11):e111373. doi: 10.15252/embj.2022111373.
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Loss of tubulin deglutamylase CCP1 causes infantile-onset neurodegeneration. Shashi V, Magiera MM, Klein D, Zaki M, Schoch K, Rudnik-Schöneborn S, Norman A, Lopes Abath Neto O, Dusl M, Yuan X, Bartesaghi L, De Marco P, Alfares AA, Marom R, Arold ST, Guzmán-Vega FJ, Pena LD, Smith EC, Steinlin M, Babiker MO, Mohassel P, Foley AR, Donkervoort S, Kaur R, Ghosh PS, Stanley V, Musaev D, Nava C, Mignot C, Keren B, Scala M, Tassano E, Picco P, Doneda P, Fiorillo C, Issa MY, Alassiri A, Alahmad A, Gerard A, Liu P, Yang Y, Ertl-Wagner B, Kranz PG, Wentzensen IM, Stucka R, Stong N, Allen AS, Goldstein DB; Undiagnosed Diseases Network, Schoser B, Rösler KM, Alfadhel M, Capra V, Chrast R, Strom TM, Kamsteeg EJ, Bönnemann CG, Gleeson JG, Martini R, Janke C, Senderek J. EMBO J. 2018 Dec 3;37(23). pii: e100540. doi: 10.15252/embj.2018100540. Epub 2018 Nov 12.
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