Doctoral Researcher Profile


Name Katja Aurbach
Affiliation Institute of Experimental Biomedicine
Chair of Experimental Biomedicine I
Street Josef-Schneider-Str. 2 D16
Zip Code 97080
City Würzburg
Email E-mail
Telephone +49 931 31- 99815
Homepage Homepage
Section Biomedicine
Title of Thesis Project Studying the role of the actin cytoskeleton and associated proteins in platelet production and function
Primary Supervisor Prof. Dr. Bernhard Nieswandt
Member of Thesis Committee PD Dr. Heike Hermanns
Dr. Dr. Paquita Nurden, Université de Bordeaux
Dr. rer. nat. Irina Pleines
Abstract
Publications

Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B. Blood Adv. 2020 May 26;4(10):2124-2134. doi: 10.1182/bloodadvances.2019001303.

Pivotal Role of PDK1 in Megakaryocyte Cytoskeletal Dynamics and Polarization during Platelet Biogenesis. Geue S, Aurbach K, Manke MC, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märklin M, Borst CE, Quintanilla-Martinez L, Rath D, Geisler T, Salih HR, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O. Blood. 2019 Nov 21;134(21):1847-1858. doi: 10.1182/blood.2019000185.

Blood collection, platelet isolation and measurement of platelet count and size in mice-a practical guide. Aurbach K, Spindler M, Haining EJ, Bender M, Pleines I. Platelets. 2019;30(6):698-707. doi: 10.1080/09537104.2018.1528345. Epub 2018 Oct 22.

CK2β critically regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis in vivo. Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O. Blood. 2017 Dec 21;130(25):2774-2785. doi: 10.1182/blood-2017-05-784413. Epub 2017 Sep 19.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia.Pleines I, Woods J, Chappaz S, Kew V, Foad N, Ballester-Beltrán J, Aurbach K, Lincetto C, Lane RM, Schevzov G, Alexander WS, Hilton DJ, Astle WJ, Downes K, Nurden P, Westbury SK, Mumford AD, Obaji SG, Collins PW, Delerue F, Ittner LM, Bryce NS, Holliday M, Lucas CA, Hardeman EC, Ouwehand WH, Gunning PW, Turro E, Tijssen MR, Kile BT. J Clin Invest. 2017 Mar 1;127(3):814-829. doi: 10.1172/JCI86154. Epub 2017 Jan 30.
Conference Contribution
Last update Publications 16.05.2020