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Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice. Englert M, Aurbach K, Becker IC, Gerber A, Heib T, Wackerbarth LM, Kusch C, Mott K, Araujo GHM, Baig AA, Dütting S, Knaus UG, Stigloher C, Schulze H, Nieswandt B, Pleines I, Nagy Z. Blood Adv. 2022 Sep 13;6(17):5184-5197. doi: 10.1182/bloodadvances.2021006545.
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Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets. Scheller I, Beck S, Göb V, Gross C, Neagoe RAI, Aurbach K, Bender M, Stegner D, Nagy Z, Nieswandt B. Haematologica. 2022 Dec 1;107(12):2846-2858. doi: 10.3324/haematol.2021.278537.
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Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B. Blood Adv. 2020 May 26;4(10):2124-2134. doi: 10.1182/bloodadvances.2019001303.
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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838.
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