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Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. Biochem Biophys Res Commun. 2022 Jul 5;612:119-125. doi: 10.1016/j.bbrc.2022.04.070. Epub 2022 Apr
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When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease. Wit M, Trujillo-Viera J, Strohmeyer A, Klingenspor M, Hankir M, Sumara G. EMBO Mol Med. 2022 May 9;14(5):e14742. doi: 10.15252/emmm.202114742. Epub 2022 Apr 19.
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Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5.
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The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, Viera JT, Valdes AL, Kolczynska K, Reuter S, Löffler MC, Erk M, Ade CP, Karwen T, Mayer AE, Eilers M, Sumara G. Genes Dev. 2020 Apr 1;34(7-8):495-510. doi: 10.1101/gad.333617.119. Epub 2020 Mar 5. |
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling. Mayer AE, Löffler MC, Loza Valdés AE, Schmitz W, El-Merahbi R, Viera JT, Erk M, Zhang T, Braun U, Heikenwalder M, Leitges M, Schulze A, Sumara G. Sci Signal. 2019 Aug 6;12(593). pii: eaav9150. doi: 10.1126/scisignal.aav9150.
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Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity. Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G. EMBO J. 2018 Nov 15;37(22):e99182. doi: 10.15252/embj.201899182. Epub 2018 Nov 2. |
Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight. Trujillo Viera J, El-Merahbi R, Nieswandt B, Stegner D, Sumara G. PLoS One. 2016 Jun 14;11(6):e0157607. doi: 10.1371/journal.pone.0157607. eCollection 2016. |
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