List Publication MScLS

The program only started in the winter semester 2012/2013. Currently (Jan 2025), of the 81 students who started over the years, 40 continued with a doctoral project in Würzburg. 23 of them have already obtained their doctorate. Additionally, 11 graduates of the program went for a doctorate elsewhere, and of those 7 have already finished their doctoral degree.

39 FOKUS students working or having worked in labs in Würzburg are authors on one or more international peer reviewed papers. FOKUS students in the list below are highlighted in bold print.

Displaying 1 - 100 of 186
Functional characterization of the DUF1127-containing small protein YjiS of Salmonella Typhimurium. Venturini E, Maaß S, Bischler T, Becher D, Vogel J, Westermann AJ. Microlife. 2025 Jan 3;6:uqae026. doi: 10.1093/femsml/uqae026. eCollection 2025.
The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron. Rüttiger AS, Ryan D, Spiga L, Lamm-Schmidt V, Prezza G, Reichardt S, Langford M, Barquist L, Faber F, Zhu W, Westermann AJ. Nat Commun. 2025 Jan 2;16(1):208. doi: 10.1038/s41467-024-55383-8.
Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription. Bhandare P, Narain A, Hofstetter J, Rummel T, Wenzel J, Schülein-Völk C, Lamer S, Eilers U, Schlosser A, Eilers M, Erhard F, Wolf E. Nucleic Acids Res. 2024 Dec 19:gkae1219. doi: 10.1093/nar/gkae1219. Online ahead of print.
Neuronal and endocrine mechanisms underlying the circadian gating of eclosion: insights from Drosophila. Wegener C, Amini E, Cavieres-Lepe J, Ewer J. Curr Opin Insect Sci. 2024 Dec;66:101286. doi: 10.1016/j.cois.2024.101286. Epub 2024 Oct 24.
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer. Reissland M, Hartmann O, Tauch S, Bugter JM, Prieto-Garcia C, Schulte C, Loebbert S, Solvie D, Bitman-Lotan E, Narain A, Jacomin AC, Schuelein-Voelk C, Fuss CT, Pahor N, Ade C, Buck V, Potente M, Li V, Beliu G, Wiegering A, Grossmann T, Eilers M, Wolf E, Maric H, Rosenfeldt M, Maurice MM, Dikic I, Gallant P, Orian A, Diefenbacher ME. Oncogene. 2024 Dec;43(50):3645-3659. doi: 10.1038/s41388-024-03141-x. Epub 2024 Oct 23.
Characterization and implementation of the MarathonRT template-switching reaction to expand the capabilities of RNA-seq. Guo LT, Grinko A, Olson S, Leipold AM, Graveley B, Saliba AE, Pyle AM. RNA. 2024 Oct 16;30(11):1495-1512. doi: 10.1261/rna.080032.124.
ReBiA-Robotic Enabled Biological Automation: 3D Epithelial Tissue Production. Königer L, Malkmus C, Mahdy D, Däullary T, Götz S, Schwarz T, Gensler M, Pallmann N, Cheufou D, Rosenwald A, Möllmann M, Groneberg D, Popp C, Groeber-Becker F, Steinke M, Hansmann J. Adv Sci (Weinh). 2024 Dec;11(45):e2406608. doi: 10.1002/advs.202406608. Epub 2024 Sep 26.
A 3D bioreactor model to study osteocyte differentiation and mechanobiology under perfusion and compressive mechanical loading. Rindt WD, Krug M, Yamada S, Sennefelder F, Belz L, Cheng WH, Azeem M, Kuric M, Evers M, Leich E, Hartmann TN, Pereira AR, Hermann M, Hansmann J, Mussoni C, Stahlhut P, Ahmad T, Yassin MA, Mustafa K, Ebert R, Jundt F. Acta Biomater. 2024 Aug;184:210-225. doi: 10.1016/j.actbio.2024.06.041. Epub 2024 Jul 4.
Circadian Control of Lipid Metabolism. Wegener C, Amatobi KM, Ozbek-Unal AG, Fekete A. Adv Exp Med Biol. 2024 Jun 15. doi: 10.1007/5584_2024_810. Online ahead of print.
Exploring T Cell Receptor Repertoires in Myocardial Diseases. Ashour D, Le Gouge K, Rainer PP, Mariotti-Ferrandiz E, Campos Ramos G. Circ Res. 2024 Jun 7;134(12):1808-1823. doi: 10.1161/CIRCRESAHA.124.323661. Epub 2024 Jun 6.
C-type natriuretic peptide/cGMP/FoxO3 signaling attenuates hyperproliferation of pericytes from patients with pulmonary arterial hypertension. Dabral S, Noh M, Werner F, Krebes L, Völker K, Maier C, Aleksic I, Novoyatleva T, Hadzic S, Schermuly RT, Perez VAJ, Kuhn M. Commun Biol. 2024 Jun 6;7(1):693. doi: 10.1038/s42003-024-06375-3.
Functional Investigation of IGF1R Mutations in Multiple Myeloma. Heredia-Guerrero SC, Evers M, Keppler S, Schwarzfischer M, Fuhr V, Rauert-Wunderlich H, Krügl A, Nedeva T, Grieb T, Pickert J, Koch H, Steinbrunn T, Bayrhof OJ, Bargou RC, Rosenwald A, Stühmer T, Leich E. Cancers (Basel). 2024 Jun 4;16(11):2139. doi: 10.3390/cancers16112139.
Susceptibility of Melanoma Cells to Targeted Therapy Correlates with Protection by Blood Neutrophils. Wendlinger S, Wohlfarth J, Siedel C, Kreft S, Kilian T, Junker S, Schmid L, Sinnberg T, Dischinger U, Heppt MV, Wistuba-Hamprecht K, Meier F, Erpenbeck L, Neubert E, Goebeler M, Gesierich A, Schrama D, Kosnopfel C, Schilling B. Cancers (Basel). 2024 May 2;16(9):1767. doi: 10.3390/cancers16091767.
An expanded transcriptome atlas for Bacteroides thetaiotaomicron reveals a small RNA that modulates tetracycline sensitivity. Ryan D, Bornet E, Prezza G, Alampalli SV, Franco de Carvalho T, Felchle H, Ebbecke T, Hayward RJ, Deutschbauer AM, Barquist L, Westermann AJ. Nat Microbiol. 2024 Apr;9(4):1130-1144. doi: 10.1038/s41564-024-01642-9. Epub 2024 Mar 25.
Proinflammatory cytokines set the stage for cardiac damage. Ashour D, Ramos G. Cardiovasc Res. 2024 Mar 13;120(2):109-110. doi: 10.1093/cvr/cvae020.
Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock in Drosophila. Cavieres-Lepe J, Amini E, Zabel M, Nässel DR, Stanewsky R, Wegener C, Ewer J. Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2308067121. doi: 10.1073/pnas.2308067121. Epub 2024 Mar 5.
CRISPR-based screening of small RNA modulators of bile susceptibility in Bacteroides thetaiotaomicron. Prezza G, Liao C, Reichardt S, Beisel CL, Westermann AJ. Proc Natl Acad Sci U S A. 2024 Feb 6;121(6):e2311323121. doi: 10.1073/pnas.2311323121. Epub 2024 Jan 31.
Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts. Trifault B, Mamontova V, Cossa G, Ganskih S, Wei Y, Hofstetter J, Bhandare P, Baluapuri A, Nieto B, Solvie D, Ade CP, Gallant P, Wolf E, Larsen DH, Munschauer M, Burger K. Nucleic Acids Res. 2024 Apr 12;52(6):3050-3068. doi: 10.1093/nar/gkae022.
CRISPR Interference-Based Functional Small RNA Genomics. Prezza G, Westermann AJ. Methods Mol Biol. 2024;2741:101-116. doi: 10.1007/978-1-0716-3565-0_6.
Sensitivities of a Rapid Test Versus an ELISA Kit for Detecting Anti-SARS-CoV-2 IgM/IgG in Sera from an Egyptian Cohort. Bahgat MM, Nasraa MH, Nadeem R, Amer K, Hassan WA, ELGarhy FM, Reda S, Fasemore AM, Förstner KU, Abd-Elshafy DN. Curr Microbiol. 2023 Nov 30;81(1):24. doi: 10.1007/s00284-023-03473-z.
Interdisciplinary studies on Coxiella burnetii: From molecular to cellular, to host, to one health research. Bauer BU, Knittler MR, Andrack J, Berens C, Campe A, Christiansen B, Fasemore AM, Fischer SF, Ganter M, Körner S, Makert GR, Matthiesen S, Mertens-Scholz K, Rinkel S, Runge M, Schulze-Luehrmann J, Ulbert S, Winter F, Frangoulidis D, Lührmann A. Int J Med Microbiol. 2023 Nov;313(6):151590. doi: 10.1016/j.ijmm.2023.151590. Epub 2023 Nov 29.
Multiple phosphorylation sites regulate the activity of the repressor Mig1 in Candida albicans. Ramírez-Zavala B, Betsova D, Schwanfelder S, Krüger I, Mottola A, Krüger T, Kniemeyer O, Brakhage AA, Morschhäuser J. mSphere. 2023 Dec 20;8(6):e0054623. doi: 10.1128/msphere.00546-23. Epub 2023 Nov 27.
Brain-to-gut trafficking of alpha-synuclein by CD11c+ cells in a mouse model of Parkinson's disease. McFleder RL, Makhotkina A, Groh J, Keber U, Imdahl F, Peña Mosca J, Peteranderl A, Wu J, Tabuchi S, Hoffmann J, Karl AK, Pagenstecher A, Vogel J, Beilhack A, Koprich JB, Brotchie JM, Saliba AE, Volkmann J, Ip CW. Nat Commun. 2023 Nov 20;14(1):7529. doi: 10.1038/s41467-023-43224-z.
TelePi: an affordable telepathology microscope camera system anyone can build and use. Youssef A, Rosenwald A, Rosenfeldt MT. Virchows Arch. 2024 Jul;485(1):115-122. doi: 10.1007/s00428-023-03685-5. Epub 2023 Nov 7.
Identification of NOTCH-driven matrisome-associated genes as prognostic indicators of multiple myeloma patient survival. Maichl DS, Kirner JA, Beck S, Cheng WH, Krug M, Kuric M, Ade CP, Bischler T, Jakob F, Hose D, Seckinger A, Ebert R, Jundt F. Blood Cancer J. 2023 Sep 5;13(1):134. doi: 10.1038/s41408-023-00907-6.
CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Mungwa ST, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M, Voutilainen MH. Brain. 2023 Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087.
Extracellular Matrix Protein-1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction. Hardy SA, Liesinger L, Patrick R, Poettler M, Rech L, Gindlhuber J, Mabotuwana NS, Ashour D, Stangl V, Bigland M, Murtha LA, Starkey MR, Scherr D, Hansbro PM, Hoefler G, Campos Ramos G, Cochain C, Harvey RP, Birner-Gruenberger R, Boyle AJ, Rainer PP. JACC Basic Transl Sci. 2023 Aug 16;8(12):1539-1554. doi: 10.1016/j.jacbts.2023.05.010. eCollection 2023 Dec.
Mapping of a major QTL for increased robustness and detection of genome assembly errors in Asian seabass (Lates calcarifer). Shen X, Niu YC, Uichanco JAV, Phua N, Bhandare P, Thevasagayam NM, Prakki SRS, Orbán L. BMC Genomics. 2023 Aug 10;24(1):449. doi: 10.1186/s12864-023-09513-z.
Platelet-derived lipids promote insulin secretion of pancreatic β cells. Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G. EMBO Mol Med. 2023 Sep 11;15(9):e16858. doi: 10.15252/emmm.202216858. Epub 2023 Jul 25.
The circadian clock is required for rhythmic lipid transport in Drosophila in interaction with diet and photic condition. Amatobi KM, Ozbek-Unal AG, Schäbler S, Deppisch P, Helfrich-Förster C, Mueller MJ, Wegener C, Fekete A. J Lipid Res. 2023 Oct;64(10):100417. doi: 10.1016/j.jlr.2023.100417. Epub 2023 Jul 20.
Advanced fluorescence microscopy in respiratory virus cell biology. Xie E, Ahmad S, Smyth RP, Sieben C. Adv Virus Res. 2023;116:123-172. doi: 10.1016/bs.aivir.2023.05.002. Epub 2023 Jul 5.
An interferon gamma response signature links myocardial aging and immunosenescence. Ashour D, Rebs S, Arampatzi P, Saliba AE, Dudek J, Schulz R, Hofmann U, Frantz S, Cochain C, Streckfuß-Bömeke K, Ramos GC. Cardiovasc Res. 2023 May 4:cvad068. doi: 10.1093/cvr/cvad068. Online ahead of print.
Prognostic value of extracellular matrix gene mutations and expression in multiple myeloma. Evers M, Schreder M, Stühmer T, Jundt F, Ebert R, Hartmann TN, Altenbuchinger M, Rudelius M, Kuric M, Rindt WD, Steinbrunn T, Langer C, Heredia-Guerrero SC, Einsele H, Bargou RC, Rosenwald A, Leich E. Blood Cancer J. 2023 Mar 23;13(1):43. doi: 10.1038/s41408-023-00817-7.
CoLoC-seq probes the global topology of organelle transcriptomes. Jeandard D, Smirnova A, Fasemore AM, Coudray L, Entelis N, Förstner KU, Tarassov I, Smirnov A. Nucleic Acids Res. 2023 Feb 22;51(3):e16. doi: 10.1093/nar/gkac1183.
An integrated transcriptomics-functional genomics approach reveals a small RNA that modulates Bacteroides thetaiotaomicron sensitivity to tetracyclines. Ryan D, Bornet E, Prezza G, Alampalli SV, de Carvalho TF, Felchle H, Ebbecke T, Hayward R, Deutschbauer AM, Barquist L, Westermann AJ. bioRxiv. 2023 Feb 16:2023.02.16.528795. doi: 10.1101/2023.02.16.528795. Preprint.
A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS. Massih B, Veh A, Schenke M, Mungwa S, Seeger B, Selvaraj BT, Chandran S, Reinhardt P, Sterneckert J, Hermann A, Sendtner M, Lüningschrör P. Front Cell Dev Biol. 2023 Feb 14;11:996952. doi: 10.3389/fcell.2023.996952. eCollection 2023.
Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy. Kuzkina A, Panzer C, Seger A, Schmitt D, Rößle J, Schreglmann SR, Knacke H, Salabasidou E, Kohl A, Sittig E, Barbe M, Berg D, Volkmann J, Sommer C, Oertel WH, Schaeffer E, Sommerauer M, Janzen A, Doppler K. Mov Disord. 2023 Feb 7. doi: 10.1002/mds.29340. Online ahead of print.
Myocardial Milieu Favors Local Differentiation of Regulatory T Cells. Delgobo M, Weiß E, Ashour D, Richter L, Popiolkowski L, Arampatzi P, Stangl V, Arias-Loza P, Mariotti-Ferrandiz E, Rainer PP, Saliba AE, Ludewig B, Hofmann U, Frantz S, Campos Ramos G. Circ Res. 2023 Mar 3;132(5):565-582. doi: 10.1161/CIRCRESAHA.122.322183. Epub 2023 Feb 6.
Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis. Kaltdorf M, Breitenbach T, Karl S, Fuchs M, Kessie DK, Psota E, Prelog M, Sarukhanyan E, Ebert R, Jakob F, Dandekar G, Naseem M, Liang C, Dandekar T. Sci Rep. 2023 Feb 1;13(1):1855. doi: 10.1038/s41598-022-27098-7.
The Impact of Tissue Preparation on Salivary Gland Tumors Investigated by Fourier-Transform Infrared Microspectroscopy. Stefanakis M, Bassler MC, Walczuch TR, Gerhard-Hartmann E, Youssef A, Scherzad A, Stöth MB, Ostertag E, Hagen R, Steinke MR, Hackenberg S, Brecht M, Meyer TJ. J Clin Med. 2023 Jan 10;12(2):569. doi: 10.3390/jcm12020569.
Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries. Soundararajan M, Marincola G, Liong O, Marciniak T, Wencker FDR, Hofmann F, Schollenbruch H, Kobusch I, Linnemann S, Wolf SA, Helal M, Semmler T, Walther B, Schoen C, Nyasinga J, Revathi G, Boelhauve M, Ziebuhr W. Microorganisms. 2022 Dec 22;11(1):31. doi: 10.3390/microorganisms11010031.
Epidemiology and antimicrobial resistance of staphylococci other than Staphylococcus aureus from domestic animals and livestock in Africa: a systematic review. Ocloo R, Nyasinga J, Munshi Z, Hamdy A, Marciniak T, Soundararajan M, Newton-Foot M, Ziebuhr W, Shittu A, Revathi G, Abouelfetouh A, Whitelaw A. Front Vet Sci. 2022 Dec 13;9:1059054. doi: 10.3389/fvets.2022.1059054. eCollection 2022.
Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice. Candemir E, Fattakhov N, Leary AO, Slattery DA, Courtney MJ, Reif A, Freudenberg F. Eur Neuropsychopharmacol. 2023 Feb;67:66-79. doi: 10.1016/j.euroneuro.2022.11.006. Epub 2022 Dec 10.
Tumor Colonization and Therapy by Escherichia coli Nissle 1917 Strain in Syngeneic Tumor-Bearing Mice Is Strongly Affected by the Gut Microbiome. Gentschev I, Petrov I, Ye M, Kafuri Cifuentes L, Toews R, Cecil A, Oelschaeger TA, Szalay AA. Cancers (Basel). 2022 Dec 7;14(24):6033. doi: 10.3390/cancers14246033.
MYC multimers shield stalled replication forks from RNA polymerase. Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23.
Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells. Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le DD, Peña Mosca J, Arellano Viera E, Kern MA, Graf C, Beyersdorf N, Lutz MB, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba AE, Ludewig B, Huehn J, Beilhack A. JCI Insight. 2022 Nov 22;7(22):e154250. doi: 10.1172/jci.insight.154250.
Proinflammatory profile in the skin of Parkinson's disease patients with and without pain. Lama J, Salabasidou E, Volkmann J, Kuzkina A, Duty S, Üçeyler N. PLoS One. 2022 Oct 27;17(10):e0276564. doi: 10.1371/journal.pone.0276564. eCollection 2022.
Identification of a novel cardiac epitope triggering T-cell responses in patients with myocardial infarction. Hapke N, Heinrichs M, Ashour D, Vogel E, Hofmann U, Frantz S, Campos Ramos G. J Mol Cell Cardiol. 2022 Dec;173:25-29. doi: 10.1016/j.yjmcc.2022.09.001. Epub 2022 Sep 16.
The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis. Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E. Front Cell Dev Biol. 2022 Sep 14;10:954358. doi: 10.3389/fcell.2022.954358. eCollection 2022.
RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells. Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A. Mol Oncol. 2022 Aug;16(15):2788-2809. doi: 10.1002/1878-0261.13265. Epub 2022 Jul 1.
An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research. An R, Strissel PL, Al-Abboodi M, Robering JW, Supachai R, Eckstein M, Peddi A, Hauck T, Bäuerle T, Boccaccini AR, Youssef A, Sun J, Strick R, Horch RE, Boos AM, Kengelbach-Weigand A. Bioengineering (Basel). 2022 Jun 27;9(7):280. doi: 10.3390/bioengineering9070280.
A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity. Vargas JG, Wagner J, Shaikh H, Lang I, Medler J, Anany M, Steinfatt T, Mosca JP, Haack S, Dahlhoff J, Büttner-Herold M, Graf C, Viera EA, Einsele H, Wajant H, Beilhack A. Front Immunol. 2022 Jun 13;13:888274. doi: 10.3389/fimmu.2022.888274. eCollection 2022.
Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, Yuan X, Genova M, Gadadhar S, Leboucher S, Birling MC, Klein D, Martini R, Janke C, Magiera MM. EMBO J. 2022 Jun 1;41(11):e111373. doi: 10.15252/embj.2022111373.
Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease. Doppler K, Mammadova S, Kuzkina A, Reetz K, Michels J, Hermann W, Sommerauer M, Volkmann J, Oertel WH, Janzen A, Sommer C. Parkinsonism Relat Disord. 2022 Jun;99:58-61. doi: 10.1016/j.parkreldis.2022.05.010. Epub 2022 May 18.
Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. Biochem Biophys Res Commun. 2022 Jul 5;612:119-125. doi: 10.1016/j.bbrc.2022.04.070. Epub 2022 Apr 27.
PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. Fischer T, Hartmann O, Reissland M, Prieto-Garcia C, Klann K, Pahor N, Schülein-Völk C, Baluapuri A, Polat B, Abazari A, Gerhard-Hartmann E, Kopp HG, Essmann F, Rosenfeldt M, Münch C, Flentje M, Diefenbacher ME. Cell Biosci. 2022 Apr 27;12(1):50. doi: 10.1186/s13578-022-00778-7.
When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease. Wit M, Trujillo-Viera J, Strohmeyer A, Klingenspor M, Hankir M, Sumara G. EMBO Mol Med. 2022 May 9;14(5):e14742. doi: 10.15252/emmm.202114742. Epub 2022 Apr 19.
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Rohlfing AK, Kolb K, Sigle M, Ziegler M, Bild A, Münzer P, Sudmann J, Dicenta V, Harm T, Manke MC, Geue S, Kremser M, Chatterjee M, Liang C, von Eysmondt H, Dandekar T, Heinzmann D, Günter M, von Ungern-Sternberg S, Büttcher M, Castor T, Mencl S, Langhauser F, Sies K, Ashour D, Beker MC, Lämmerhofer M, Autenrieth SE, Schäffer TE, Laufer S, Szklanna P, Maguire P, Heikenwalder M, Müller KAL, Hermann DM, Kilic E, Stumm R, Ramos G, Kleinschnitz C, Borst O, Langer HF, Rath D, Gawaz M. Nat Commun. 2022 Apr 5;13(1):1823. doi: 10.1038/s41467-022-29341-1.
Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma. Riedel A, Helal M, Pedro L, Swietlik JJ, Shorthouse D, Schmitz W, Haas L, Young T, da Costa ASH, Davidson S, Bhandare P, Wolf E, Hall BA, Frezza C, Oskarsson T, Shields JD. Cancer Immunol Res. 2022 Apr 1;10(4):482-497. doi: 10.1158/2326-6066.CIR-21-0778.
Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice. Mainz L, Sarhan MAFE, Roth S, Sauer U, Kalogirou C, Eckstein M, Gerhard-Hartmann E, Seibert HD, Voelker HU, Geppert C, Rosenwald A, Eilers M, Schulze A, Diefenbacher M, Rosenfeldt MT. Autophagy. 2022 Dec;18(12):2880-2893. doi: 10.1080/15548627.2022.2052588. Epub 2022 Mar 28.
Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging. Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP. Nat Struct Mol Biol. 2022 Apr;29(4):306-319. doi: 10.1038/s41594-022-00746-2. Epub 2022 Mar 28. Author Correction: Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging. Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP. Nat Struct Mol Biol. 2023 Mar;30(3):403. doi: 10.1038/s41594-023-00946-4.
Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53. Mainz L, Sarhan MAFE, Roth S, Sauer U, Maurus K, Hartmann EM, Seibert HD, Rosenwald A, Diefenbacher ME, Rosenfeldt MT. Front Cell Dev Biol. 2022 Mar 16;10:785252. doi: 10.3389/fcell.2022.785252. eCollection 2022.
NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. doi: 10.1073/pnas.2105691119.
Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot-Marie-Tooth 1A. Klein D, Groh J, Yuan X, Berve K, Stassart R, Fledrich R, Martini R. Glia. 2022 Jun;70(6):1100-1116. doi: 10.1002/glia.24158. Epub 2022 Feb 21.
The brain of Cataglyphis ants: neuronal organization and visual projections. Habenstein J, Amini E, Grübel K, El Jundi B, Rössler W. Sci Rep. 2022 Feb 21;12(1):2855. doi: 10.1038/s41598-022-06368-4.
Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'. Lisack J, Morriswood B, Engstler M. Elife. 2022 Feb 1;11:e75922. doi: 10.7554/eLife.75922.
Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U. Nat Commun. 2022 Jan 12;13(1):281. doi: 10.1038/s41467-021-27704-8.
Susceptibility of Human Airway Tissue Models Derived From Different Anatomical Sites to Bordetella pertussis and Its Virulence Factor Adenylate Cyclase Toxin. Sivarajan R, Kessie DK, Oberwinkler H, Pallmann N, Walles T, Scherzad A, Hackenberg S, Steinke M. Front Cell Infect Microbiol. 2021 Dec 23;11:797491. doi: 10.3389/fcimb.2021.797491. eCollection 2021.
CoxBase: an Online Platform for Epidemiological Surveillance, Visualization, Analysis, and Typing of Coxiella burnetii Genomic Sequences. Fasemore AM, Helbich A, Walter MC, Dandekar T, Vergnaud G, Förstner KU, Frangoulidis D. mSystems. 2021 Dec 21;6(6):e0040321. doi: 10.1128/mSystems.00403-21. Epub 2021 Dec 21.
A Suppressor Mutation in the β-Subunit Kis1 Restores Functionality of the SNF1 Complex in Candida albicans snf4Δ Mutants. Ramírez-Zavala B, Mottola A, Krüger I, Morschhäuser J. mSphere. 2021 Dec 22;6(6):e0092921. doi: 10.1128/msphere.00929-21. Epub 2021 Dec 15.
MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts. Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29.
The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Heinrichs M, Ashour D, Siegel J, Büchner L, Wedekind G, Heinze KG, Arampatzi P, Saliba AE, Cochain C, Hofmann U, Frantz S, Campos Ramos G. Cardiovasc Res. 2021 Nov 22;117(13):2664-2676. doi: 10.1093/cvr/cvab181.
Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells. Adhikari B, Narain A, Wolf E. STAR Protoc. 2021 Nov 19;2(4):100949. doi: 10.1016/j.xpro.2021.100949. eCollection 2021 Dec 17.
Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study. Kuzkina A, Bargar C, Schmitt D, Rößle J, Wang W, Schubert AL, Tatsuoka C, Gunzler SA, Zou WQ, Volkmann J, Sommer C, Doppler K, Chen SG. NPJ Parkinsons Dis. 2021 Nov 15;7(1):99. doi: 10.1038/s41531-021-00242-2.
Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines. Kessie DK, Rudel T. PLoS Biol. 2021 Nov 12;19(11):e3001462. doi: 10.1371/journal.pbio.3001462. eCollection 2021 Nov.
Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention. Vignoli B, Sansevero G, Sasi M, Rimondini R, Blum R, Bonaldo V, Biasini E, Santi S, Berardi N, Lu B, Canossa M. Commun Biol. 2021 Oct 5;4(1):1152. doi: 10.1038/s42003-021-02678-x.
Endocrine signals fine-tune daily activity patterns in Drosophila. Pauls D, Selcho M, Räderscheidt J, Amatobi KM, Fekete A, Krischke M, Hermann-Luibl C, Ozbek-Unal AG, Ehmann N, Itskov PM, Kittel RJ, Helfrich-Förster C, Kühnlein RP, Mueller MJ, Wegener C. Curr Biol. 2021 Sep 27;31(18):4076-4087.e5. doi: 10.1016/j.cub.2021.07.002. Epub 2021 Jul 29.
Perturbations in plant energy homeostasis prime lateral root initiation via SnRK1-bZIP63-ARF19 signaling. Muralidhara P, Weiste C, Collani S, Krischke M, Kreisz P, Draken J, Feil R, Mair A, Teige M, Müller MJ, Schmid M, Becker D, Lunn JE, Rolland F, Hanson J, Dröge-Laser W. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2106961118. doi: 10.1073/pnas.2106961118.
Müller R, Fasemore AM, Elhossary M, Förstner KU; Proceedings of the Second Teaching Machine Learning and Artificial Intelligence Workshop, PMLR, 2021, 170:68-72
RNA Structures and Their Role in Selective Genome Packaging. Ye L, Ambi UB, Olguin-Nava M, Gribling-Burrer AS, Ahmad S, Bohn P, Weber MM, Smyth RP. Viruses. 2021 Sep 8;13(9):1788. doi: 10.3390/v13091788.
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells. Stelzner K, Boyny A, Hertlein T, Sroka A, Moldovan A, Paprotka K, Kessie D, Mehling H, Potempa J, Ohlsen K, Fraunholz MJ, Rudel T. PLoS Pathog. 2021 Sep 2;17(9):e1009874. doi: 10.1371/journal.ppat.1009874. eCollection 2021 Sep.
Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. Freudenberg F, Candemir E, Chen X, Li LL, Esen-Sehir D, Schenk N, Kinoshita M, Grünewald L, Frerichs V, Fattakhov N, Manchen J, Bikas S, Kumar A, OLeary A, Slattery DA, von Engelhardt J, Courtney MJ, Reif A. EBioMedicine. 2021 Sep;71:103565. doi: 10.1016/j.ebiom.2021.103565. Epub 2021 Aug 27.
Comparative genomics provides structural and functional insights into Bacteroides RNA biology. Prezza G, Ryan D, Mädler G, Reichardt S, Barquist L, Westermann AJ. Mol Microbiol. 2021 Aug 11. doi: 10.1111/mmi.14793. Online ahead of print.
Unexpected plasticity in the life cycle of Trypanosoma brucei. Schuster S, Lisack J, Subota I, Zimmermann H, Reuter C, Mueller T, Morriswood B, Engstler M. Elife. 2021 Aug 6;10:e66028. doi: 10.7554/eLife.66028.
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder. Miglis MG, Adler CH, Antelmi E, Arnaldi D, Baldelli L, Boeve BF, Cesari M, Dall'Antonia I, Diederich NJ, Doppler K, Dušek P, Ferri R, Gagnon JF, Gan-Or Z, Hermann W, Högl B, Hu MT, Iranzo A, Janzen A, Kuzkina A, Lee JY, Leenders KL, Lewis SJG, Liguori C, Liu J, Lo C, Ehgoetz Martens KA, Nepozitek J, Plazzi G, Provini F, Puligheddu M, Rolinski M, Rusz J, Stefani A, Summers RLS, Yoo D, Zitser J, Oertel WH. Lancet Neurol. 2021 Aug;20(8):671-684. doi: 10.1016/S1474-4422(21)00176-9.
Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F, Baluapuri A, Wolf E. Mol Cell. 2021 Aug 5;81(15):3110-3127.e14. doi: 10.1016/j.molcel.2021.06.016. Epub 2021 Jul 6.
Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Shaikh H, Vargas JG, Mokhtari Z, Jarick KJ, Ulbrich M, Mosca JP, Viera EA, Graf C, Le DD, Heinze KG, Büttner-Herold M, Rosenwald A, Pezoldt J, Huehn J, Beilhack A. Front Immunol. 2021 Jul 26;12:689896. doi: 10.3389/fimmu.2021.689896. eCollection 2021.
Physical exercise mitigates neuropathic changes in an animal model for Charcot-Marie-Tooth disease 1X. Klein D, Yuan X, Weiß EM, Martini R. Exp Neurol. 2021 Sep;343:113786. doi: 10.1016/j.expneurol.2021.113786. Epub 2021 Jun 19.
MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma. Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M. Cancer Res. 2021 Aug 15;81(16):4242-4256. doi: 10.1158/0008-5472.CAN-21-1677. Epub 2021 Jun 18.
A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism. Loza-Valdes A, Mayer AE, Kassouf T, Trujillo-Viera J, Schmitz W, Dziaczkowski F, Leitges M, Schlosser A, Sumara G. Life Sci Alliance. 2021 Jun 18;4(8):e202000863. doi: 10.26508/lsa.202000863. Print 2021 Aug.
Coping with sterile inflammation: between risk and necessity. Ashour D, Delgobo M, Frantz S, Ramos GC. Cardiovasc Res. 2021 May 25;117(6):e84-e87. doi: 10.1093/cvr/cvab157.
The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans. Mottola A, Ramírez-Zavala B, Hünniger K, Kurzai O, Morschhäuser J. Mol Microbiol. 2021 Aug;116(2):483-497. doi: 10.1111/mmi.14727. Epub 2021 May 11.
Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5.
Consistent skin α-synuclein positivity in REM sleep behavior disorder - A two center two-to-four-year follow-up study. Doppler K, Antelmi E, Kuzkina A, Donadio V, Incensi A, Plazzi G, Pizza F, Marelli S, Ferini-Strambi L, Tinazzi M, Mayer G, Sittig E, Booij J, Sedghi A, Oertel WH, Volkmann J, Sommer C, Janzen A, Liguori R. Parkinsonism Relat Disord. 2021 May;86:108-113. doi: 10.1016/j.parkreldis.2021.04.007. Epub 2021 Apr 17.
Accumulation of cytotoxic T cells in the aged CNS leads to axon degeneration and contributes to cognitive and motor decline. Groh J, Knöpper K, Arampatzi P, Yuan X, Lößlein L, Saliba AE, Kastenmüller W, Martini R. Nat Aging. 2021 Apr;1(4):357-367. doi: 10.1038/s43587-021-00049-z. Epub 2021 Apr 15.
Reprogramming of host glutamine metabolism during Chlamydia trachomatis infection and its key role in peptidoglycan synthesis. Rajeeve K, Vollmuth N, Janaki-Raman S, Wulff TF, Baluapuri A, Dejure FR, Huber C, Fink J, Schmalhofer M, Schmitz W, Sivadasan R, Eilers M, Wolf E, Eisenreich W, Schulze A, Seibel J, Rudel T. Nat Microbiol. 2021 Apr;6(4):533. doi: 10.1038/s41564-021-00874-3.
Natural Zeitgebers Under Temperate Conditions Cannot Compensate for the Loss of a Functional Circadian Clock in Timing of a Vital Behavior in Drosophila. Ruf F, Mitesser O, Mungwa ST, Horn M, Rieger D, Hovestadt T, Wegener C. J Biol Rhythms. 2021 Jun;36(3):271-285. doi: 10.1177/0748730421998112. Epub 2021 Mar 22.
Dermal and cardiac autonomic fiber involvement in Parkinson's disease and multiple system atrophy. Brumberg J, Kuzkina A, Lapa C, Mammadova S, Buck A, Volkmann J, Sommer C, Isaias IU, Doppler K. Neurobiol Dis. 2021 Jun;153:105332. doi: 10.1016/j.nbd.2021.105332. Epub 2021 Mar 17.
Novel molecular subgroups within the context of receptor tyrosine kinase and adhesion signalling in multiple myeloma. Leich E, Schreder M, Pischimarov J, Stühmer T, Steinbrunn T, Rudelius M, Brünnert D, Chatterjee M, Langer C, Keppler S, Heredia-Guerrero SC, Einsele H, Knop S, Bargou RC, Rosenwald A. Blood Cancer J. 2021 Mar 4;11(3):51. doi: 10.1038/s41408-021-00442-2.
Implementation of CRISPR/Cas9 Genome Editing to Generate Murine Lung Cancer Models That Depict the Mutational Landscape of Human Disease. Hartmann O, Reissland M, Maier CR, Fischer T, Prieto-Garcia C, Baluapuri A, Schwarz J, Schmitz W, Garrido-Rodriguez M, Pahor N, Davies CC, Bassermann F, Orian A, Wolf E, Schulze A, Calzado MA, Rosenfeldt MT, Diefenbacher ME. Front Cell Dev Biol. 2021 Mar 2;9:641618. doi: 10.3389/fcell.2021.641618. eCollection 2021.

Pages