The program only started in the winter semester 2012/2013. Currently (May 2023), of the 70 students who started into the program over the years, 38 have begun or already finished a doctoral project at JMU, 10 others started or already finished their PhD somewhere else. Of those who started at JMU, 33 are authors on one or more international peer reviewed publications. FOKUS students are highlighted in bold print.
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CDNF rescues motor neurons in models of amyotrophic lateral sclerosis by targeting endoplasmic reticulum stress. De Lorenzo F, Lüningschrör P, Nam J, Beckett L, Pilotto F, Galli E, Lindholm P, Rüdt von Collenberg C, Mungwa ST, Jablonka S, Kauder J, Thau-Habermann N, Petri S, Lindholm D, Saxena S, Sendtner M, Saarma M, Voutilainen MH. Brain. 2023 Sep 1;146(9):3783-3799. doi: 10.1093/brain/awad087. |
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Mapping of a major QTL for increased robustness and detection of genome assembly errors in Asian seabass (Lates calcarifer). Shen X, Niu YC, Uichanco JAV, Phua N, Bhandare P, Thevasagayam NM, Prakki SRS, Orbán L. BMC Genomics. 2023 Aug 10;24(1):449. doi: 10.1186/s12864-023-09513-z. |
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Platelet-derived lipids promote insulin secretion of pancreatic β cells. Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G. EMBO Mol Med. 2023 Sep 11;15(9):e16858. doi: 10.15252/emmm.202216858. Epub 2023 Jul 25. |
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The circadian clock is required for rhythmic lipid transport in Drosophila in interaction with diet and photic condition. Amatobi KM, Ozbek-Unal AG, Schäbler S, Deppisch P, Helfrich-Förster C, Mueller MJ, Wegener C, Fekete A. J Lipid Res. 2023 Oct;64(10):100417. doi: 10.1016/j.jlr.2023.100417. Epub 2023 Jul 20. |
| An interferon gamma response signature links myocardial aging and immunosenescence. Ashour D, Rebs S, Arampatzi P, Saliba AE, Dudek J, Schulz R, Hofmann U, Frantz S, Cochain C, Streckfuß-Bömeke K, Ramos GC. Cardiovasc Res. 2023 May 4:cvad068. doi: 10.1093/cvr/cvad068. Online ahead of print. |
| Prognostic value of extracellular matrix gene mutations and expression in multiple myeloma. Evers M, Schreder M, Stühmer T, Jundt F, Ebert R, Hartmann TN, Altenbuchinger M, Rudelius M, Kuric M, Rindt WD, Steinbrunn T, Langer C, Heredia-Guerrero SC, Einsele H, Bargou RC, Rosenwald A, Leich E. Blood Cancer J. 2023 Mar 23;13(1):43. doi: 10.1038/s41408-023-00817-7. |
| CoLoC-seq probes the global topology of organelle transcriptomes. Jeandard D, Smirnova A, Fasemore AM, Coudray L, Entelis N, Förstner KU, Tarassov I, Smirnov A. Nucleic Acids Res. 2023 Feb 22;51(3):e16. doi: 10.1093/nar/gkac1183. |
| An integrated transcriptomics-functional genomics approach reveals a small RNA that modulates Bacteroides thetaiotaomicron sensitivity to tetracyclines. Ryan D, Bornet E, Prezza G, Alampalli SV, de Carvalho TF, Felchle H, Ebbecke T, Hayward R, Deutschbauer AM, Barquist L, Westermann AJ. bioRxiv. 2023 Feb 16:2023.02.16.528795. doi: 10.1101/2023.02.16.528795. Preprint. |
| A 3D cell culture system for bioengineering human neuromuscular junctions to model ALS. Massih B, Veh A, Schenke M, Mungwa S, Seeger B, Selvaraj BT, Chandran S, Reinhardt P, Sterneckert J, Hermann A, Sendtner M, Lüningschrör P. Front Cell Dev Biol. 2023 Feb 14;11:996952. doi: 10.3389/fcell.2023.996952. eCollection 2023. |
| Dermal Real-Time Quaking-Induced Conversion Is a Sensitive Marker to Confirm Isolated Rapid Eye Movement Sleep Behavior Disorder as an Early α-Synucleinopathy. Kuzkina A, Panzer C, Seger A, Schmitt D, Rößle J, Schreglmann SR, Knacke H, Salabasidou E, Kohl A, Sittig E, Barbe M, Berg D, Volkmann J, Sommer C, Oertel WH, Schaeffer E, Sommerauer M, Janzen A, Doppler K. Mov Disord. 2023 Feb 7. doi: 10.1002/mds.29340. Online ahead of print. |
| Software JimenaE allows efficient dynamic simulations of Boolean networks, centrality and system state analysis. Kaltdorf M, Breitenbach T, Karl S, Fuchs M, Kessie DK, Psota E, Prelog M, Sarukhanyan E, Ebert R, Jakob F, Dandekar G, Naseem M, Liang C, Dandekar T. Sci Rep. 2023 Feb 1;13(1):1855. doi: 10.1038/s41598-022-27098-7. |
| The Impact of Tissue Preparation on Salivary Gland Tumors Investigated by Fourier-Transform Infrared Microspectroscopy. Stefanakis M, Bassler MC, Walczuch TR, Gerhard-Hartmann E, Youssef A, Scherzad A, Stöth MB, Ostertag E, Hagen R, Steinke MR, Hackenberg S, Brecht M, Meyer TJ. J Clin Med. 2023 Jan 10;12(2):569. doi: 10.3390/jcm12020569. |
| Farming Practice Influences Antimicrobial Resistance Burden of Non-Aureus Staphylococci in Pig Husbandries. Soundararajan M, Marincola G, Liong O, Marciniak T, Wencker FDR, Hofmann F, Schollenbruch H, Kobusch I, Linnemann S, Wolf SA, Helal M, Semmler T, Walther B, Schoen C, Nyasinga J, Revathi G, Boelhauve M, Ziebuhr W. Microorganisms. 2022 Dec 22;11(1):31. doi: 10.3390/microorganisms11010031. |
| Epidemiology and antimicrobial resistance of staphylococci other than Staphylococcus aureus from domestic animals and livestock in Africa: a systematic review. Ocloo R, Nyasinga J, Munshi Z, Hamdy A, Marciniak T, Soundararajan M, Newton-Foot M, Ziebuhr W, Shittu A, Revathi G, Abouelfetouh A, Whitelaw A. Front Vet Sci. 2022 Dec 13;9:1059054. doi: 10.3389/fvets.2022.1059054. eCollection 2022. |
| Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice. Candemir E, Fattakhov N, Leary AO, Slattery DA, Courtney MJ, Reif A, Freudenberg F. Eur Neuropsychopharmacol. 2023 Feb;67:66-79. doi: 10.1016/j.euroneuro.2022.11.006. Epub 2022 Dec 10. |
| Tumor Colonization and Therapy by Escherichia coli Nissle 1917 Strain in Syngeneic Tumor-Bearing Mice Is Strongly Affected by the Gut Microbiome. Gentschev I, Petrov I, Ye M, Kafuri Cifuentes L, Toews R, Cecil A, Oelschaeger TA, Szalay AA. Cancers (Basel). 2022 Dec 7;14(24):6033. doi: 10.3390/cancers14246033. |
| MYC multimers shield stalled replication forks from RNA polymerase. Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. |
| Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells. Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le DD, Peña Mosca J, Arellano Viera E, Kern MA, Graf C, Beyersdorf N, Lutz MB, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba AE, Ludewig B, Huehn J, Beilhack A. JCI Insight. 2022 Nov 22;7(22):e154250. doi: 10.1172/jci.insight.154250. |
| Proinflammatory profile in the skin of Parkinson's disease patients with and without pain. Lama J, Salabasidou E, Volkmann J, Kuzkina A, Duty S, Üçeyler N. PLoS One. 2022 Oct 27;17(10):e0276564. doi: 10.1371/journal.pone.0276564. eCollection 2022. |
| Identification of a novel cardiac epitope triggering T-cell responses in patients with myocardial infarction. Hapke N, Heinrichs M, Ashour D, Vogel E, Hofmann U, Frantz S, Campos Ramos G. J Mol Cell Cardiol. 2022 Dec;173:25-29. doi: 10.1016/j.yjmcc.2022.09.001. Epub 2022 Sep 16. |
| The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis. Schwarz JD, Lukassen S, Bhandare P, Eing L, Snaebjörnsson MT, García YC, Kisker JP, Schulze A, Wolf E. Front Cell Dev Biol. 2022 Sep 14;10:954358. doi: 10.3389/fcell.2022.954358. eCollection 2022. |
| RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells. Otto C, Kastner C, Schmidt S, Uttinger K, Baluapuri A, Denk S, Rosenfeldt MT, Rosenwald A, Roehrig F, Ade CP, Schuelein-Voelk C, Diefenbacher ME, Germer CT, Wolf E, Eilers M, Wiegering A. Mol Oncol. 2022 Aug;16(15):2788-2809. doi: 10.1002/1878-0261.13265. Epub 2022 Jul 1. |
| An Innovative Arteriovenous (AV) Loop Breast Cancer Model Tailored for Cancer Research. An R, Strissel PL, Al-Abboodi M, Robering JW, Supachai R, Eckstein M, Peddi A, Hauck T, Bäuerle T, Boccaccini AR, Youssef A, Sun J, Strick R, Horch RE, Boos AM, Kengelbach-Weigand A. Bioengineering (Basel). 2022 Jun 27;9(7):280. doi: 10.3390/bioengineering9070280. |
| A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity. Vargas JG, Wagner J, Shaikh H, Lang I, Medler J, Anany M, Steinfatt T, Mosca JP, Haack S, Dahlhoff J, Büttner-Herold M, Graf C, Viera EA, Einsele H, Wajant H, Beilhack A. Front Immunol. 2022 Jun 13;13:888274. doi: 10.3389/fimmu.2022.888274. eCollection 2022. |
| Distinct roles of α- and β-tubulin polyglutamylation in controlling axonal transport and in neurodegeneration. Bodakuntla S, Yuan X, Genova M, Gadadhar S, Leboucher S, Birling MC, Klein D, Martini R, Janke C, Magiera MM. EMBO J. 2022 Jun 1;41(11):e111373. doi: 10.15252/embj.2022111373. |
| Association between probable REM sleep behavior disorder and increased dermal alpha-synuclein deposition in Parkinson's disease. Doppler K, Mammadova S, Kuzkina A, Reetz K, Michels J, Hermann W, Sommerauer M, Volkmann J, Oertel WH, Janzen A, Sommer C. Parkinsonism Relat Disord. 2022 Jun;99:58-61. doi: 10.1016/j.parkreldis.2022.05.010. Epub 2022 May 18. |
| PTEN mutant non-small cell lung cancer require ATM to suppress pro-apoptotic signalling and evade radiotherapy. Fischer T, Hartmann O, Reissland M, Prieto-Garcia C, Klann K, Pahor N, Schülein-Völk C, Baluapuri A, Polat B, Abazari A, Gerhard-Hartmann E, Kopp HG, Essmann F, Rosenfeldt M, Münch C, Flentje M, Diefenbacher ME. Cell Biosci. 2022 Apr 27;12(1):50. doi: 10.1186/s13578-022-00778-7. |
| Targeting ERK3/MK5 complex for treatment of obesity and diabetes. Loza-Valdes A, El-Merahbi R, Kassouf T, Demczuk A, Reuter S, Viera JT, Karwen T, Noh M, Löffler MC, Romero-Becerra R, Torres JL, Marcos M, Sabio G, Wojda U, Sumara G. Biochem Biophys Res Commun. 2022 Jul 5;612:119-125. doi: 10.1016/j.bbrc.2022.04.070. Epub 2022 Apr 27. |
| When fat meets the gut-focus on intestinal lipid handling in metabolic health and disease. Wit M, Trujillo-Viera J, Strohmeyer A, Klingenspor M, Hankir M, Sumara G. EMBO Mol Med. 2022 May 9;14(5):e14742. doi: 10.15252/emmm.202114742. Epub 2022 Apr 19. |
| Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma. Riedel A, Helal M, Pedro L, Swietlik JJ, Shorthouse D, Schmitz W, Haas L, Young T, da Costa ASH, Davidson S, Bhandare P, Wolf E, Hall BA, Frezza C, Oskarsson T, Shields JD. Cancer Immunol Res. 2022 Apr 1;10(4):482-497. doi: 10.1158/2326-6066.CIR-21-0778. |
| Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice. Mainz L, Sarhan MAFE, Roth S, Sauer U, Kalogirou C, Eckstein M, Gerhard-Hartmann E, Seibert HD, Voelker HU, Geppert C, Rosenwald A, Eilers M, Schulze A, Diefenbacher M, Rosenfeldt MT. Autophagy. 2022 Dec;18(12):2880-2893. doi: 10.1080/15548627.2022.2052588. Epub 2022 Mar 28. |
| Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging. Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP. Nat Struct Mol Biol. 2022 Apr;29(4):306-319. doi: 10.1038/s41594-022-00746-2. Epub 2022 Mar 28. Author Correction: Short- and long-range interactions in the HIV-1 5' UTR regulate genome dimerization and packaging. Ye L, Gribling-Burrer AS, Bohn P, Kibe A, Börtlein C, Ambi UB, Ahmad S, Olguin-Nava M, Smith M, Caliskan N, von Kleist M, Smyth RP. Nat Struct Mol Biol. 2023 Mar;30(3):403. doi: 10.1038/s41594-023-00946-4. |
| Autophagy Blockage Reduces the Incidence of Pancreatic Ductal Adenocarcinoma in the Context of Mutant Trp53. Mainz L, Sarhan MAFE, Roth S, Sauer U, Maurus K, Hartmann EM, Seibert HD, Rosenwald A, Diefenbacher ME, Rosenfeldt MT. Front Cell Dev Biol. 2022 Mar 16;10:785252. doi: 10.3389/fcell.2022.785252. eCollection 2022. |
| NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer. Doffo J, Bamopoulos SA, Köse H, Orben F, Zang C, Pons M, den Dekker AT, Brouwer RWW, Baluapuri A, Habringer S, Reichert M, Illendula A, Krämer OH, Schick M, Wolf E, van IJcken WFJ, Esposito I, Keller U, Schneider G, Wirth M. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2105691119. doi: 10.1073/pnas.2105691119. |
| The brain of Cataglyphis ants: neuronal organization and visual projections. Habenstein J, Amini E, Grübel K, El Jundi B, Rössler W. Sci Rep. 2022 Feb 21;12(1):2855. doi: 10.1038/s41598-022-06368-4. |
| Early targeting of endoneurial macrophages alleviates the neuropathy and affects abnormal Schwann cell differentiation in a mouse model of Charcot-Marie-Tooth 1A. Klein D, Groh J, Yuan X, Berve K, Stassart R, Fledrich R, Martini R. Glia. 2022 Jun;70(6):1100-1116. doi: 10.1002/glia.24158. Epub 2022 Feb 21. |
| Response to comment on 'Unexpected plasticity in the life cycle of Trypanosoma Brucei'. Lisack J, Morriswood B, Engstler M. Elife. 2022 Feb 1;11:e75922. doi: 10.7554/eLife.75922. |
| Genetic alterations of the SUMO isopeptidase SENP6 drive lymphomagenesis and genetic instability in diffuse large B-cell lymphoma. Schick M, Zhang L, Maurer S, Maurer HC, Isaakaidis K, Schneider L, Patra U, Schunck K, Rohleder E, Hofstetter J, Baluapuri A, Scherger AK, Slotta-Huspenina J, Hettler F, Weber J, Engleitner T, Maresch R, Slawska J, Lewis R, Istvanffy R, Habringer S, Steiger K, Baiker A, Oostendorp RAJ, Miething C, Lenhof HP, Bassermann F, Chapuy B, Wirth M, Wolf E, Rad R, Müller S, Keller U. Nat Commun. 2022 Jan 12;13(1):281. doi: 10.1038/s41467-021-27704-8. |
| Susceptibility of Human Airway Tissue Models Derived From Different Anatomical Sites to Bordetella pertussis and Its Virulence Factor Adenylate Cyclase Toxin. Sivarajan R, Kessie DK, Oberwinkler H, Pallmann N, Walles T, Scherzad A, Hackenberg S, Steinke M. Front Cell Infect Microbiol. 2021 Dec 23;11:797491. doi: 10.3389/fcimb.2021.797491. eCollection 2021. |
| CoxBase: an Online Platform for Epidemiological Surveillance, Visualization, Analysis, and Typing of Coxiella burnetii Genomic Sequences. Fasemore AM, Helbich A, Walter MC, Dandekar T, Vergnaud G, Förstner KU, Frangoulidis D. mSystems. 2021 Dec 21;6(6):e0040321. doi: 10.1128/mSystems.00403-21. Epub 2021 Dec 21. |
| A Suppressor Mutation in the β-Subunit Kis1 Restores Functionality of the SNF1 Complex in Candida albicans snf4Δ Mutants. Ramírez-Zavala B, Mottola A, Krüger I, Morschhäuser J. mSphere. 2021 Dec 22;6(6):e0092921. doi: 10.1128/msphere.00929-21. Epub 2021 Dec 15. |
| MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts. Papadopoulos D, Solvie D, Baluapuri A, Endres T, Ha SA, Herold S, Kalb J, Giansanti C, Schülein-Völk C, Ade CP, Schneider C, Gaballa A, Vos S, Fischer U, Dobbelstein M, Wolf E, Eilers M. Mol Cell. 2022 Jan 6;82(1):159-176.e12. doi: 10.1016/j.molcel.2021.11.002. Epub 2021 Nov 29. |
| The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Heinrichs M, Ashour D, Siegel J, Büchner L, Wedekind G, Heinze KG, Arampatzi P, Saliba AE, Cochain C, Hofmann U, Frantz S, Campos Ramos G. Cardiovasc Res. 2021 Nov 22;117(13):2664-2676. doi: 10.1093/cvr/cvab181. |
| The healing myocardium mobilizes a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Heinrichs M, Ashour D, Siegel J, Büchner L, Wedekind G, Heinze KG, Arampatzi P, Saliba AE, Cochain C, Hofmann U, Frantz S, Campos Ramos G. Cardiovasc Res. 2021 Nov 22;117(13):2664-2676. doi: 10.1093/cvr/cvab181. |
| Generation of auxin inducible degron (AID) knock-in cell lines for targeted protein degradation in mammalian cells. Adhikari B, Narain A, Wolf E. STAR Protoc. 2021 Nov 19;2(4):100949. doi: 10.1016/j.xpro.2021.100949. eCollection 2021 Dec 17. |
| Diagnostic value of skin RT-QuIC in Parkinson's disease: a two-laboratory study. Kuzkina A, Bargar C, Schmitt D, Rößle J, Wang W, Schubert AL, Tatsuoka C, Gunzler SA, Zou WQ, Volkmann J, Sommer C, Doppler K, Chen SG. NPJ Parkinsons Dis. 2021 Nov 15;7(1):99. doi: 10.1038/s41531-021-00242-2. |
| Advanced human mucosal tissue models are needed to improve preclinical testing of vaccines. Kessie DK, Rudel T. PLoS Biol. 2021 Nov 12;19(11):e3001462. doi: 10.1371/journal.pbio.3001462. eCollection 2021 Nov. |
| Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention. Vignoli B, Sansevero G, Sasi M, Rimondini R, Blum R, Bonaldo V, Biasini E, Santi S, Berardi N, Lu B, Canossa M. Commun Biol. 2021 Oct 5;4(1):1152. doi: 10.1038/s42003-021-02678-x. |
| Endocrine signals fine-tune daily activity patterns in Drosophila. Pauls D, Selcho M, Räderscheidt J, Amatobi KM, Fekete A, Krischke M, Hermann-Luibl C, Ozbek-Unal AG, Ehmann N, Itskov PM, Kittel RJ, Helfrich-Förster C, Kühnlein RP, Mueller MJ, Wegener C. Curr Biol. 2021 Sep 27;31(18):4076-4087.e5. doi: 10.1016/j.cub.2021.07.002. Epub 2021 Jul 29. |
| Perturbations in plant energy homeostasis prime lateral root initiation via SnRK1-bZIP63-ARF19 signaling. Muralidhara P, Weiste C, Collani S, Krischke M, Kreisz P, Draken J, Feil R, Mair A, Teige M, Müller MJ, Schmid M, Becker D, Lunn JE, Rolland F, Hanson J, Dröge-Laser W. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2106961118. doi: 10.1073/pnas.2106961118. |
| Müller R, Fasemore AM, Elhossary M, Förstner KU; Proceedings of the Second Teaching Machine Learning and Artificial Intelligence Workshop, PMLR, 2021, 170:68-72 |
| RNA Structures and Their Role in Selective Genome Packaging. Ye L, Ambi UB, Olguin-Nava M, Gribling-Burrer AS, Ahmad S, Bohn P, Weber MM, Smyth RP. Viruses. 2021 Sep 8;13(9):1788. doi: 10.3390/v13091788. |
| Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells. Stelzner K, Boyny A, Hertlein T, Sroka A, Moldovan A, Paprotka K, Kessie D, Mehling H, Potempa J, Ohlsen K, Fraunholz MJ, Rudel T. PLoS Pathog. 2021 Sep 2;17(9):e1009874. doi: 10.1371/journal.ppat.1009874. eCollection 2021 Sep. |
| Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. Freudenberg F, Candemir E, Chen X, Li LL, Esen-Sehir D, Schenk N, Kinoshita M, Grünewald L, Frerichs V, Fattakhov N, Manchen J, Bikas S, Kumar A, OLeary A, Slattery DA, von Engelhardt J, Courtney MJ, Reif A. EBioMedicine. 2021 Sep;71:103565. doi: 10.1016/j.ebiom.2021.103565. Epub 2021 Aug 27. |
| Comparative genomics provides structural and functional insights into Bacteroides RNA biology. Prezza G, Ryan D, Mädler G, Reichardt S, Barquist L, Westermann AJ. Mol Microbiol. 2021 Aug 11. doi: 10.1111/mmi.14793. Online ahead of print. |
| Unexpected plasticity in the life cycle of Trypanosoma brucei. Schuster S, Lisack J, Subota I, Zimmermann H, Reuter C, Mueller T, Morriswood B, Engstler M. Elife. 2021 Aug 6;10:e66028. doi: 10.7554/eLife.66028. |
| Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder. Miglis MG, Adler CH, Antelmi E, Arnaldi D, Baldelli L, Boeve BF, Cesari M, Dall'Antonia I, Diederich NJ, Doppler K, Dušek P, Ferri R, Gagnon JF, Gan-Or Z, Hermann W, Högl B, Hu MT, Iranzo A, Janzen A, Kuzkina A, Lee JY, Leenders KL, Lewis SJG, Liguori C, Liu J, Lo C, Ehgoetz Martens KA, Nepozitek J, Plazzi G, Provini F, Puligheddu M, Rolinski M, Rusz J, Stefani A, Summers RLS, Yoo D, Zitser J, Oertel WH. Lancet Neurol. 2021 Aug;20(8):671-684. doi: 10.1016/S1474-4422(21)00176-9. |
| Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination. Narain A, Bhandare P, Adhikari B, Backes S, Eilers M, Dölken L, Schlosser A, Erhard F, Baluapuri A, Wolf E. Mol Cell. 2021 Aug 5;81(15):3110-3127.e14. doi: 10.1016/j.molcel.2021.06.016. Epub 2021 Jul 6. |
| Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Shaikh H, Vargas JG, Mokhtari Z, Jarick KJ, Ulbrich M, Mosca JP, Viera EA, Graf C, Le DD, Heinze KG, Büttner-Herold M, Rosenwald A, Pezoldt J, Huehn J, Beilhack A. Front Immunol. 2021 Jul 26;12:689896. doi: 10.3389/fimmu.2021.689896. eCollection 2021. |
| Physical exercise mitigates neuropathic changes in an animal model for Charcot-Marie-Tooth disease 1X. Klein D, Yuan X, Weiß EM, Martini R. Exp Neurol. 2021 Sep;343:113786. doi: 10.1016/j.expneurol.2021.113786. Epub 2021 Jun 19. |
| MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma. Krenz B, Gebhardt-Wolf A, Ade CP, Gaballa A, Roehrig F, Vendelova E, Baluapuri A, Eilers U, Gallant P, D'Artista L, Wiegering A, Gasteiger G, Rosenfeldt MT, Bauer S, Zender L, Wolf E, Eilers M. Cancer Res. 2021 Aug 15;81(16):4242-4256. doi: 10.1158/0008-5472.CAN-21-1677. Epub 2021 Jun 18. |
| A phosphoproteomic approach reveals that PKD3 controls PKA-mediated glucose and tyrosine metabolism. Loza-Valdes A, Mayer AE, Kassouf T, Trujillo-Viera J, Schmitz W, Dziaczkowski F, Leitges M, Schlosser A, Sumara G. Life Sci Alliance. 2021 Jun 18;4(8):e202000863. doi: 10.26508/lsa.202000863. Print 2021 Aug. |
| Coping with sterile inflammation: between risk and necessity. Ashour D, Delgobo M, Frantz S, Ramos GC. Cardiovasc Res. 2021 May 25;117(6):e84-e87. doi: 10.1093/cvr/cvab157. |
| The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans. Mottola A, Ramírez-Zavala B, Hünniger K, Kurzai O, Morschhäuser J. Mol Microbiol. 2021 Aug;116(2):483-497. doi: 10.1111/mmi.14727. Epub 2021 May 11. |
| Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity. Trujillo-Viera J, El-Merahbi R, Schmidt V, Karwen T, Loza-Valdes A, Strohmeyer A, Reuter S, Noh M, Wit M, Hawro I, Mocek S, Fey C, Mayer AE, Löffler MC, Wilhelmi I, Metzger M, Ishikawa E, Yamasaki S, Rau M, Geier A, Hankir M, Seyfried F, Klingenspor M, Sumara G. EMBO Mol Med. 2021 May 7;13(5):e13548. doi: 10.15252/emmm.202013548. Epub 2021 May 5. |
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| The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S. Oncogene. 2020 Oct;39(44):6841-6855. doi: 10.1038/s41388-020-01477-8. Epub 2020 Sep 25. Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E, Meierjohann S. Oncogene. 2020 Oct;39(44):6841-6855. doi: 10.1038/s41388-020-01477-8. Epub 2020 Sep 25. |
| An RNA-centric view on gut Bacteroidetes. Ryan D, Prezza G, Westermann AJ. Biol Chem. 2020 Sep 24;402(1):55-72. doi: 10.1515/hsz-2020-0230. Print 2020 Nov 18. |
| Generation of Viable Candida albicans Mutants Lacking the "Essential" Protein Kinase Snf1 by Inducible Gene Deletion. Mottola A, Schwanfelder S, Morschhäuser J. mSphere. 2020 Aug 19;5(4):e00805-20. doi: 10.1128/mSphere.00805-20. |
| Grad-seq shines light on unrecognized RNA and protein complexes in the model bacterium Escherichia coli. Hör J, Di Giorgio S, Gerovac M, Venturini E, Förstner KU, Vogel J. Nucleic Acids Res. 2020 Aug 19:gkaa676. doi: 10.1093/nar/gkaa676. Online ahead of print. |
| Induction of BDNF expression in layer II/III and layer V neurons of the motor cortex is essential for motor learning. Andreska T, Rauskolb S, Scheffler N, Lüningschrör P, Sasi M, Signoret-Genest J, Behringer M, Blum R, Sauer M, Tovote P, Sendtner M. J Neurosci. 2020 Jul 10:JN-RM-0288-20. doi: 10.1523/JNEUROSCI.0288-20.2020. Online ahead of print. |
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| IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction. Ashour D, Arampatzi P, Pavlovic V, Förstner KU, Kaisho T, Beilhack A, Erhard F, Lutz MB. JCI Insight. 2020 May 21;5(10):135143. doi: 10.1172/jci.insight.135143. |
| Improved bacterial RNA-seq by Cas9-based depletion of ribosomal RNA reads. Prezza G, Heckel T, Dietrich S, Homberger C, Westermann AJ, Vogel J. RNA. 2020 Apr 28. pii: rna.075945.120. doi: 10.1261/rna.075945.120. [Epub ahead of print] |
| Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus. Rose C, Casas-Sánchez A, Dyer NA, Solórzano C, Beckett AJ, Middlehurst B, Marcello M, Haines LR, Lisack J, Engstler M, Lehane MJ, Prior IA, Acosta-Serrano Á. Nat Microbiol. 2020 Jul;5(7):909-916. doi: 10.1038/s41564-020-0707-z. Epub 2020 Apr 20.. |
| Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing. Karunakaran MM, Willcox CR, Salim M, Paletta D, Fichtner AS, Noll A, Starick L, Nöhren A, Begley CR, Berwick KA, Chaleil RAG, Pitard V, Déchanet-Merville J, Bates PA, Kimmel B, Knowles TJ, Kunzmann V, Walter L, Jeeves M, Mohammed F, Willcox BE, Herrmann T. Immunity. 2020 Mar 17;52(3):487-498.e6. doi: 10.1016/j.immuni.2020.02.014. Epub 2020 Mar 9. |
| The adrenergic-induced ERK3 pathway drives lipolysis and suppresses energy dissipation. El-Merahbi R, Viera JT, Valdes AL, Kolczynska K, Reuter S, Löffler MC, Erk M, Ade CP, Karwen T, Mayer AE, Eilers M, Sumara G. Genes Dev. 2020 Apr 1;34(7-8):495-510. doi: 10.1101/gad.333617.119. Epub 2020 Mar 5. |
| Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset. Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6697-6707. doi: 10.1073/pnas.1909474117. Epub 2020 Mar 5. |
| Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function. Forero A, Ku HP, Malpartida AB, Wäldchen S, Alhama-Riba J, Kulka C, Aboagye B, Norton WHJ, Young AMJ, Ding YQ, Blum R, Sauer M, Rivero O, Lesch KP. Neuropharmacology. 2020 May 15;168:108018. doi: 10.1016/j.neuropharm.2020.108018. Epub 2020 Feb 28. |
| Target gene-independent functions of MYC oncoproteins. Baluapuri A, Wolf E, Eilers M. Nat Rev Mol Cell Biol. 2020 May;21(5):255-267. doi: 10.1038/s41580-020-0215-2. Epub 2020 Feb 18. |
| Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines. Weißbach S, Heredia-Guerrero SC, Barnsteiner S, Großhans L, Bodem J, Starz H, Langer C, Appenzeller S, Knop S, Steinbrunn T, Rost S, Einsele H, Bargou RC, Rosenwald A, Stühmer T, Leich E. Cancers (Basel). 2020 Feb 16;12(2). pii: E455. doi: 10.3390/cancers12020455. |
| Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Cossa G, Roeschert I, Prinz F, Baluapuri A, Silveira Vidal R, Schülein-Völk C, Chang YC, Ade CP, Mastrobuoni G, Girard C, Wortmann L, Walz S, Lührmann R, Kempa S, Kuster B, Wolf E, Mumberg D, Eilers M. Mol Cell. 2020 Mar 19;77(6):1322-1339.e11. doi: 10.1016/j.molcel.2020.01.008. Epub 2020 Jan 31. |
| Loss of function in the Drosophila clock gene period results in altered intermediary lipid metabolism and increased susceptibility to starvation. Schäbler S, Amatobi KM, Horn M, Rieger D, Helfrich-Förster C, Mueller MJ, Wegener C, Fekete A. Cell Mol Life Sci. 2020 Dec;77(23):4939-4956. doi: 10.1007/s00018-019-03441-6. Epub 2020 Jan 20. |
| K5 Capsule and Lipopolysaccharide Are Important in Resistance to T4 Phage Attack in Probiotic E. coli Strain Nissle 1917. Soundararajan M, von Bünau R, Oelschlaeger TA. Front Microbiol. 2019 Nov 29;10:2783. doi: 10.3389/fmicb.2019.02783. eCollection 2019. |
| A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A. Nat Cell Biol. 2019 Nov;21(11):1413-1424. doi: 10.1038/s41556-019-0408-0. Epub 2019 Nov 4. |